Bosentan Impurity 1

Product Description
CAT No.
ALN-B017012
CAS No.
1257099-41-4
Mol. F.
C22H27N5O6S
Mol. Wt.
489.6
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Product Overview
Technical Data
Reference
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Product Overview
Chemical Name : 4-(Tert-butyl)-N-(5-hydroxy-6-(2-(2-hydroxyethoxy)ethoxy)-[2,2′-bipyrimidin]-4-yl)benzenesulfonamide
Smiles : O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=C(O)C(OCCOCCO)=NC(C3=NC=CC=N3)=N2)=O
Technical Data
Reference
Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist
Peter J. Harrington, Hiralal N. Khatri, Brad S. DeHoff, Martin R. Guinn, Mark A. Boehler, and Karl A. GlasernOrganic Process Research & Development 2002, 6, 120u2212124
Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist
Sanjay A. Jadhav,1 Shashikant B. Landge,1 Sonali L. Jadhav,1 Navanath C. Niphade,1 Saroj R. Bembalkar,2 and Vijayavitthal T. Mathad1 – E-Hindawi Access to Research Chromatography Research International Volume 2011, Article ID 929876, 9 pages
Development and validation of a stability indicating analytical method for the related substances of Bosentan drug substance by HPLC
Mubeen Ahmad Khan, Sukumar Sinha, Mangesh Todkar, Vikas Parashar, K. Swamy Reddy – Am. J. Sci. Ind. Res., 2012, 3(2): 69-80
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