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Nicardipine Nitroso Impurity

Nicardipine Nitroso Impurity

Product Description
CAT No.
ALN-N004016
CAS No.
NA
Mol. F.
C26H28N4O7
Mol. Wt.
508.5
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RFQ
Chemical Name : 3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Smiles : O=C(C1=C(C)N(N=O)C(C)=C(C(OCCN(CC2=CC=CC=C2)C)=O)C1C3=CC=CC([N+]([O-])=O)=C3)OC
Inchi : InChI=1S/C14H21N7O6/c1-7(2)9(15)13(24)26-4-8(3-22)27-6-20-5-17-10-11(23)18-14(16)21(19-25)12(10)20/h5,7-9,22H,3-4,6,15H2,1-2H3,(H2,16,18,23)/t8?,9-/m0/s1

Stability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS

Sheikha M.Al-Ghannam,Abeer M.Al-OlayannArabian Journal of Chemistry Volume 12, Issue 8, December 2019, Pages 1983-1993

Employing ionization behaviors to resolve a trace-level impurity: determination of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid di-2-[methyl-(phenylmethyl)amino]ethyl ester in nicardipine drug substance

M B Maurin 1, R D Vickery, P Ma, J Manalo, M A Hussain – Pharm Res. 1992 Nov;9(11):1518-20.

Chromatographic purity and assay of nicardipine by HPLC

C. V. Fernández\xa0 D. F. Mira\xa0 G. I. Luque – Journal of High Resolution Chromatography Volume13, Issue12 December 1990 Pages 846-849

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