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Apremilast D8

Apremilast D8

Product Description
CAT No.
ALN-A051D02
CAS No.
1258597-45-3
Mol. F.
C22H16D8N2O7S
Mol. Wt.
468.6
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Chemical Name : (S)-N-(2-(1-(3-(Ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
Smiles : C[S](C[C@H](C1=CC(OC([2H])([2H])C([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C1)N(C(C2=CC=C3)=O)C(C2=C3NC(C)=O)=O)(=O)=O
Inchi : InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1/i1D3,5D2

Identification and characterization of process-related substances and degradation products in apremilast: process optimization and degradation pathway elucidation

Yuting Lu, Xiaoyue Shen, Taijun Hang, Min SongnJ Pharm Biomed Anal. 2017 Jul 15;141:70-78

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-r Inhibitor

Hon-Wah Man, Peter Schafer, Lu Min Wong, Rebecca T. Patterson, Laura G. Corral, Heather Raymon, Kate Blease, Jim Leisten, Michael A. Shirley, Yang Tang, Darius M. Babusis, Roger Chen, Dave Stirling, and George W. Muller – J. Med. Chem. 2009, 52, 1522–1524

Identification, characterization and HPLC quantification for impurities of Apremilast

Kaihe Xionga , Xingling Mab , Na Caob ,Lei Liub ,Lili Suna , Qiaogen Zoub , Ping Wei – Analytical Methods 8(8)

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