Apremilast Impurity 24
Product Description
CAT No.
ALN-A051040
CAS No.
NA
Mol. F.
C20H24N2O7S
Mol. Wt.
436.5
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Product Overview
Technical Data
Reference
RFQ
Product Overview
Chemical Name : (S)-2-Amino-6-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoic acid
Smiles : COC1=CC=C([C@H](NC(C2=C(C(O)=O)C(N)=CC=C2)=O)CS(C)(=O)=O)C=C1OCC
Inchi : InChI=1S/C7H7Cl/c8-6-7-4-2-1-3-5-7/h1-5H,6H2
Technical Data
Reference
Identification and characterization of process-related substances and degradation products in apremilast: process optimization and degradation pathway elucidation
Yuting Lu, Xiaoyue Shen, Taijun Hang, Min SongnJ Pharm Biomed Anal. 2017 Jul 15;141:70-78
Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-r Inhibitor
Hon-Wah Man, Peter Schafer, Lu Min Wong, Rebecca T. Patterson, Laura G. Corral, Heather Raymon, Kate Blease, Jim Leisten, Michael A. Shirley, Yang Tang, Darius M. Babusis, Roger Chen, Dave Stirling, and George W. Muller – J. Med. Chem. 2009, 52, 1522–1524
Identification, characterization and HPLC quantification for impurities of Apremilast
Kaihe Xionga , Xingling Mab , Na Caob ,Lei Liub ,Lili Suna , Qiaogen Zoub , Ping Wei – Analytical Methods 8(8)
RFQ