Aprepitant Open-Ring Methyl Ester Impurity

Product Description
CAT No.
ALN-A030030
CAS No.
219821-37-1
Mol. F.
C24H25F7N4O4
Mol. Wt.
566.5
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Product Overview
Technical Data
Reference
RFQ
Product Overview
Chemical Name : Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholino)-1-iminoethyl)hydrazinecarboxylate ;
Smiles : N=C(NNC(OC)=O)CN1[C@@H](C2=CC=C(F)C=C2)[C@@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)OCC1
Inchi : InChI=1S/C23H21F7N4O4/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)38-20-19(13-2-4-17(24)5-3-13)34(36,6-7-37-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-,34?/m1/s1
Technical Data
Reference
Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli VastardinJournal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161
Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,
Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya
RFQ