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Aprepitant (R,S,R)-Isomer

Aprepitant (R,S,R)-Isomer

Product Description
CAT No.
ALN-A030002
CAS No.
1185502-97-9
Mol. F.
C23H21F7N4O3
Mol. Wt.
534.4
Stock
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Chemical Name : 5-([(2S,3R)-2-((R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
Smiles : O=C1NN=C(CN2[C@H](C3=CC=C(F)C=C3)[C@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)OCC2)N1
Inchi : InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
Synonym : (1R,2S,3R) Aprepitant ; (2S,3R,1’R)-Aprepitant

Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept

Constantinos K. Zacharis, Elli VastardinJournal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161

Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy

Roy Helmy,

Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances

George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya

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