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Ascomycin

Ascomycin

Product Description
CAT No.
ALN-A033001
CAS No.
104987-12-4
Mol. F.
C43H69NO12
Mol. Wt.
792
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RFQ
Chemical Name : (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-Ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Smiles : O=C(C([C@]1(O)O[C@]([H])([C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]2CC)[C@@H](OC)C[C@H]1C)=O)N3CCCC[C@@]3([H])C(O[C@H](/C(C)=C/[C@@H]4CC[C@@H](O)[C@H](OC)C4)[C@H](C)[C@@H](O)CC2=O)=O
Inchi : InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1
Synonym : Ascomycin ; Tacrolimus USP RC A ; Tacrolimus Desmethylene Impurity ; Immunomycin

Analysis of ascomycin production enhanced by shikimic acid resistance and addition in Streptomyces hygroscopicus var. ascomyceticus

Haishan Qi a, Sumin Zhaoa, Jianping Wena,b,c,u2217, Yunlin Chend, Xiaoqiang JianBiochemical Engineering Journal 82 (2014) 124u2013133

Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725

Zhiguo Song,

Chemistry of the Immunomodulatory Macrolide Ascomycin and Related Analogues

Anthony DeMarco, Mangzhu Zhao, Edward G. Corley, Andrew S. Thompson, James McNamara, Yulan Li, Dale Rieger, Paul Sohar, David J. Mathre, David M. Tschaen, Robert A. Reamer, Martha F. Huntington, Guo-Jie Ho, Fuh-Rong Tsay, Khateeta Emerson, Richard Shuman, Edward J. J. Grabowski, and Paul J. Reider – J. Org. Chem. 1999, 64, 1859-1867

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