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Ketoconazole EP Impurity D

Ketoconazole EP Impurity D

Product Description
CAT No.
ALN-K001005
CAS No.
67914-61-8
Mol. F.
C24H26Cl2N4O3
Mol. Wt.
489.4
Stock
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Chemical Name : 1-[4-[[(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine (as per EP)
Smiles : ClC(C=C1)=CC(Cl)=C1[C@](OC2)(CN3C=CN=C3)O[C@H]2COC(C=C4)=CC=C4N5CCNCC5
Inchi : InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26+/m1/s1
Synonym : N-Desacetyl Ketoconazole

Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresisu2013mass spectrometry

Maru00b4u0131a Castro-Puyana a, Carmen Garcu00b4u0131a-Ruiz a, Alejandro Cifuentes b, Antonio L. Crego a, Maria Luisa MarinanJournal of Chromatography A, 1114 (2006) 170u2013177

Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor

Aneta Grycová , Aneta Do?i?áková 1, Zden?k Dvo?ák – Toxicol Lett . 2015 Dec 3;239(2):67-72

Ion-pairing liquid chromatographic method determination of ketoconazole and stress degradation in pharmaceutical formulations with fluorescence detection

Wisanu Thongchai – Brazilian Journal of Pharmaceutical Sciences Sci. vol.56

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