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Methotrexate EP Impurity B

Methotrexate EP Impurity B

Product Description
CAT No.
ALN-M019026
CAS No.
54-62-6
Mol. F.
C19H20N8O5
Mol. Wt.
440.4
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RFQ
Chemical Name : (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
Smiles : NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C3)=N2)=N1
Inchi : InChI=1S/C23H30NO4.BrH/c1-16(2)24(5,17(3)4)14-15-27-22(25)23(26)18-10-6-8-12-20(18)28-21-13-9-7-11-19(21)23;/h6-13,16-17,26H,14-15H2,1-5H3;1H/q+1;/p-1
Synonym : Methotrexate USP Related Compound B ; Aminopterin ; 4-aminofolic acid

Identification and Quantitation of Impurities in Methotrexate

dulal c. chatterji, altice g. frazier, and joseph f. gallellnJournal of Pharmaceutical Sciences Volume 67, Issue 5, May 1978, Pages 622-624

determination of methotrexate and its major metabolite, 7_hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection

mark c. roach, philippe gozel and richard n. zare – Journal of Chromatography, 426 (1988) 129-140

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples

Forough Karami , Sara Ranjbar\xa0 , Younes Ghasemi , Manica Negahdaripour – Journal of Pharmaceutical Analysis 9 (2019) 373-391

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