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Methotrexate Hydrate EP Impurity B

Methotrexate Hydrate EP Impurity B

Product Description
CAT No.
ALN-M019003
CAS No.
1217459-90-9
Mol. F.
C19H20N8O5 : H2O
Mol. Wt.
440.4 : 18.0
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RFQ
Chemical Name : (4-(((2,4-diaminopteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid hydrate
Smiles : NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C3)=N2)=N1.O
Inchi : InChI=1S/C7H8N6O/c8-5-4-6(13-7(9)12-5)10-1-3(2-14)11-4/h1,14H,2H2,(H4,8,9,10,12,13)
Synonym : Methotrexate USP Related Compound B

Identification and Quantitation of Impurities in Methotrexate

dulal c. chatterji, altice g. frazier, and joseph f. gallellnJournal of Pharmaceutical Sciences Volume 67, Issue 5, May 1978, Pages 622-624

determination of methotrexate and its major metabolite, 7_hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection

mark c. roach, philippe gozel and richard n. zare – Journal of Chromatography, 426 (1988) 129-140

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples

Forough Karami , Sara Ranjbar\xa0 , Younes Ghasemi , Manica Negahdaripour – Journal of Pharmaceutical Analysis 9 (2019) 373-391

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