Nadolol EP Impurity B

Product Description
CAT No.
ALN-N002003
CAS No.
NA
Mol. F.
C14H20O5
Mol. Wt.
268.3
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Product Overview
Technical Data
Reference
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Product Overview
Chemical Name : Cis-5-[(2RS)-2-hydroxy-3-methoxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol (as per EP)
Smiles : OC(COC)COC1=CC=CC2=C1C[C@@H](O)[C@@H](O)C2
Inchi : InChI=1S/C13H18O5/c14-6-9(15)7-18-13-3-1-2-8-4-11(16)12(17)5-10(8)13/h1-3,9,11-12,14-17H,4-7H2/t9?,11-,12+/m0/s1
Synonym : Nadolol USP Related Compound B
Technical Data
Reference
Nadolol: high-pressure liquid chromatographic methods for assay, racemate composition and related compounds
pauline m. lacroix,t norman m. curran and edward g. loveringnJournal of Pharmaceutical & Biomedical Analysis Vol. 10, Nos 10-12, pp. 917-924, 1992
The nonmetabolized u03b2u2011blocker nadolol is a substrate of oct1, oct2, mate1, mate2-k, and pu2011glycoprotein, but not of oatp1b1 and oatp1b3
Shingen Misaka, Jana Knop, Katrin Singer, Eva Hoier, Markus Keiser, Fabian Mu?ller, Hartmut Glaeser, Jo? rg Ko? nig, and Martin F. Fromm – Mol. Pharmaceutics 2016, 13, 2, 512–519
Separation of nadolol racemates by high pH reversed-phase preparative chromatography
Rami S. Arafaha,b , António E. Ribeiroa,b , Alírio E. Rodriguesc , Luís S. Pais – Separation and Purification Technology Volume 233, 15 February 2020, 116018
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