Nadolol Impurity 1

Product Description
CAT No.
ALN-N002009
CAS No.
NA
Mol. F.
C26H35NO8
Mol. Wt.
489.6
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Product Overview
Technical Data
Reference
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Product Overview
Chemical Name : (2S,2’S,3R,3’R)-5,5′-((Azanediylbis(2-hydroxypropane-3,1-diyl))bis(oxy))bis(1,2,3,4-tetrahydronaphthalene-2,3-diol)
Smiles : OC(CNCC(O)COC1=C(C[C@@H](O)[C@@H](O)C2)C2=CC=C1)COC3=CC=CC4=C3C[C@@H](O)[C@@H](O)C4
Inchi : InChI=1S/C37H43N3O6.ClH/c1-7-45-35(41)32-25(2)38-26(3)33(34(32)29-19-14-20-30(23-29)40(43)44)36(42)46-37(4,5)24-39(6)22-21-31(27-15-10-8-11-16-27)28-17-12-9-13-18-28;/h8-20,23,31,34,38H,7,21-22,24H2,1-6H3;1H/t34-;/m1./s1
Technical Data
Reference
Nadolol: high-pressure liquid chromatographic methods for assay, racemate composition and related compounds
pauline m. lacroix,t norman m. curran and edward g. loveringnJournal of Pharmaceutical & Biomedical Analysis Vol. 10, Nos 10-12, pp. 917-924, 1992
The nonmetabolized u03b2u2011blocker nadolol is a substrate of oct1, oct2, mate1, mate2-k, and pu2011glycoprotein, but not of oatp1b1 and oatp1b3
Shingen Misaka, Jana Knop, Katrin Singer, Eva Hoier, Markus Keiser, Fabian Mu?ller, Hartmut Glaeser, Jo? rg Ko? nig, and Martin F. Fromm – Mol. Pharmaceutics 2016, 13, 2, 512–519
Separation of nadolol racemates by high pH reversed-phase preparative chromatography
Rami S. Arafaha,b , António E. Ribeiroa,b , Alírio E. Rodriguesc , Luís S. Pais – Separation and Purification Technology Volume 233, 15 February 2020, 116018
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