Nicardipine Dehydro Carboxylic Acid Impurity

Product Description
CAT No.
ALN-N004010
CAS No.
64603-72-1
Mol. F.
C16H14N2O6
Mol. Wt.
330.3
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Product Overview
Technical Data
Reference
RFQ
Product Overview
Chemical Name : 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid
Smiles : O=C(O)C1=C(C)N=C(C)C(C(OC)=O)=C1C2=CC=CC([N+]([O-])=O)=C2
Inchi : InChI=1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-6-5-7-12(8-11)19(22)23/h5-8H,1-4H3
Synonym : Nicardipine Pyridine Monoacid Impurity
Technical Data
Reference
Stability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS
Sheikha M.Al-Ghannam,Abeer M.Al-OlayannArabian Journal of Chemistry Volume 12, Issue 8, December 2019, Pages 1983-1993
Employing ionization behaviors to resolve a trace-level impurity: determination of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid di-2-[methyl-(phenylmethyl)amino]ethyl ester in nicardipine drug substance
M B Maurin 1, R D Vickery, P Ma, J Manalo, M A Hussain – Pharm Res. 1992 Nov;9(11):1518-20.
Chromatographic purity and assay of nicardipine by HPLC
C. V. Fernández\xa0 D. F. Mira\xa0 G. I. Luque – Journal of High Resolution Chromatography Volume13, Issue12 December 1990 Pages 846-849
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