Spironolactone EP Impurity D

Product Description
CAT No.
ALN-S017005
CAS No.
NA
Mol. F.
C24H32O4S2
Mol. Wt.
448.6
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Product Overview
Technical Data
Reference
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Product Overview
Chemical Name : S-[(2′R)-3,5′-Dioxo-3′,4′-dihydro-5′H-spiro[androst-4-ene-17,2′-furan]-7α-yl] ethane(dithioperoxate) (as per EP)
(2′R)-7α-(Acetyldisulfanyl)-3′,4′-dihydro-5′H-spiro[androst-4-ene-17,2′-furan]-3,5′-dione (as per USP)
Smiles : C[C@@]12[C@]3(CCC(O3)=O)CC[C@@]1([H])[C@]4([H])[C@H](SSC(C)=O)CC5=CC(CC[C@]5(C)[C@@]4([H])CC2)=O
Inchi : InChI=1S/C22H30O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h13,16-18H,3-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
Synonym : Spironolactone USP Related Compound D ; Disulfanyl Spironolactone
Technical Data
Reference
RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.nFrom Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J. – From Asian Journal of Chemistry (2020), 32(2), 219-227.
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata – From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.
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