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Abemaciclib D10

Abemaciclib D10

Product Description
CAT No.
ALN-A077D02
CAS No.
2088650-71-7
Mol. F.
C27H22D10F2N8
Mol. Wt.
516.7
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Chemical Name : N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-(methyl-d3)-1-(propan-2-yl-d7)-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
Smiles : FC1=C2C(N(C(C([2H])([2H])[2H])=N2)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=CC(C3=NC(NC4=CC=C(CN5CCN(CC)CC5)C=N4)=NC=C3F)=C1
Inchi : InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)/i8D2,9D2,10D2,11D2

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry

By Martinez-Chavez, Alejandra; Rosing, Hilde; Hillebrand, Michel; Tibben, Matthijs; Schinkel, Alfred H.; Beijnen, Jos H.nFrom Analytical and Bioanalytical Chemistry (2019), 411(20), 5331-5345

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